Introduction: Because of the special nature of their patients, recent burnout studies on burnout began to focus on pediatric rather than general nurses. However, these studies mostly concentrate on selected covariates and lack comprehensiveness. Objectives: This paper aims to suggest a holistic theoretical model on burnout covariates among pediatric nurses. Methods: This systematic review utilized a systematic search strategy in four databases and the PRISMA guidelines to retrieve and summarize studies investigating pediatric nurses’ burnout. Results: Out of 78 retrieved articles, 21 relevant studies were included in our synthesis. Conclusion: The proposed model includes a wide range of burnout covariates. These covariates were categorized into contributing factors (e.g. COVID-19 pandemic, and poor work engagement) or consequences (e.g. poor well-being, and patient adverse events). This model might be a comprehensive approach and guide for future studies addressing pediatric nurses’ burnout. Future studies should test the suggested theoretical model by assessing the contributing factors and consequences of burnout.