Background: Dry Eye Disease (DED) is a common disease in the ophthalmic world, characterized by eye irritation, foreign body sensation, stinging, photophobia, and blurred vision. Objective: This study aimed to measure the quality of life (QOL) for dry eye participants among An-Najah University students.

Methods: A cross-sectional study was used. Students aged between 17 and 24 years were selected based on a convenient selection; the total number of research subjects was 481. Data was collected in two steps at the same time: The first step includes giving the student the Ocular Surface Disease Index (OSDI) to diagnose if they have a dry eye disease or not. Then they are asked to fill out the Visual Function Questionnaire (VFQ-25) to know how DED affects their QOL.

Results: The prevalence of dry eyes in Palestine was 69.4%. Also, it revealed that dry eyes are significantly associated with QOL, which has an impact on students’ daily life activities.

Conclusion: Our results have shown that quality of life is inversely proportioned with dry eye severity, showing that dry eye affects a person’s daily life activities.

Implication For Nursing: The findings in this study may increase nurses' awareness regarding DED and offer appreciated data for public health promotion in adolescents. Additional investigation is vital to have a better understanding of additional probable parameters linked to DED.