Background: Effective communication is a fundamental component of nursing practice and plays a key role in strengthening nurse–patient relationships and improving healthcare quality. Objectives: This study aimed to evaluate the effect of a communication skills training program on nursing staff communication skills before and after implementation from the patients’ perspective. Methods: A quantitative quasi-experimental study with an independent pre- and post-intervention design was conducted at Latakia University Hospital, Syria. A convenience sample of 200 patients participated (100 before and 100 after the intervention). Patients assessed nurses’ communication skills using a structured questionnaire covering verbal communication, non-verbal communication, listening, and persuasion skills. Data were analyzed using SPSS version 25 using descriptive statistics, chi-square tests, and independent t-tests. Results: Significant improvements were observed in overall nursing communication skills after training (p ≤ 0.01), especially in verbal communication and listening. Conclusion: Structured communication training programs can effectively enhance nurses’ communication skills and improve nurse–patient interactions, supporting better patient care.