Background: Fatigue and pain are common and distressing symptoms among patients undergoing hemodialysis, negatively affecting their daily functioning and quality of life. Nonpharmacological interventions, such as relaxation techniques, may offer a safe and effective approach to managing these symptoms.

Objectives: To evaluate the effect of relaxation techniques on fatigue and pain levels among patients undergoing hemodialysis.

Methods: A quasi-experimental study with a two-group design was conducted on 80 patients undergoing hemodialysis, who were assigned to either an experimental group or a control group (40 patients in each group). The experimental group received a structured relaxation program during hemodialysis sessions, while the control group received routine care only. Fatigue and pain were assessed before and after the intervention using standardized measurement tools.

Data were analyzed using nonparametric statistical tests (Mann–Whitney U test and Wilcoxon signed-rank test).

This study was a quasi‑experimental nursing intervention conducted within routine clinical care and was not pre‑registered in a clinical trial registry.

Results: The experimental group demonstrated a statistically significant reduction in fatigue compared with the control group (p < .001). Within-group analysis revealed significant reductions in both fatigue and pain following the relaxation intervention.

Conclusions: Relaxation techniques were associated with a statistically significant reduction in fatigue and pain and may serve as a beneficial adjunctive intervention for patients undergoing hemodialysis.

Implications for Nursing: Integrating relaxation techniques into routine nursing care may enhance nurses’ role in nonpharmacological symptom management and improve patient-centered care in hemodialysis units.